Hypotonic and Yellowish Newborn



Doctor's Information

Name : Morteza
Family : Sanei Taheri
Affiliation :Radiology Department,Shohada Tajrish Hospital,SBMU
Academic Degree : Associate Professor of Radiology
Email : This email address is being protected from spambots. You need JavaScript enabled to view it.
Resident : Mohsen Zakavati Avval


Case Section

Pediatric Radiology


Patient's Information

Gender : Male
Age : 1


Clinical Summary

We present the case of a premature newborn with low weight at birth. His problem list was jaundice, hypotonia, difficulty feeding and respiration.


Imaging Findings

A CT scan of the brain, showing multiple calcifications in periventricular regions.


Differential Diagnosis



Final Diagnosis

Congenital cerebral toxoplasmosis


Discussion (Related Text)

Congenital toxoplasmosis is a disease that occurs in fetuses infected with Toxoplasma gondii (a protozoan parasite). It can cause miscarriage or stillbirth. It can also cause serious and progressive visual, hearing, motor, cognitive, and other problems in a child. There are approximately 400 to 4,000 cases of congenital toxoplasmosis each year in the United States.[1] Congenital cerebral toxoplasmosis is a manifestation of congenital toxoplasmosis and refers to development of cerebral toxoplasmosis in the fetus through maternal transmission. [2] Pathology: From an infected mother, toxoplasma can be transmitted to 17% fetuses in first trimester, 25% in second trimester and 65% in third trimester. Radiographic features: Ultrasound, CT or MRI images may show multiple calcifications in periventricular regions, basal ganglia and corticomedullary junction. Obstructive hydrocephalus may be seen. Other associated findings are • migrational anomalies • cerebral / cerebellar atrophy • encephalomalacia • hydranencephaly • microcephaly



1. Rose Kivi, Congenital Toxoplasmosis. http://www.healthline.com, Published on July 18, 2012 2. Dr Jeremy Jones and Dr Praveen Jha et al. Congenital cerebral toxoplasmosis. Radiopedia.org 3. Berry. Diagnostic Radiology : Neuroradiology : Head and Neck Imaging. Jaypee Brothers Medical Publishers (P) Ltd. ISBN:8180616363. Read it at Google Books - Find it at Amazon 4. Wallon M, Liou C, Garner P et-al. Congenital toxoplasmosis: systematic review of evidence of efficacy of treatment in pregnancy. BMJ. 1999;318 (7197): 1511-4. BMJ (link) - Free text at pubmed - Pubmed citation


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